Scientists of M.K. Ammosov North-Eastern Federal University begin working with immortalized HepG2 cells - modified cancer cells of the liver, the press service of the university reports.
According to experts of the cellular technologies and regenerative medicine laboratory, their potential is incredibly high.
Although HepG2 hepatocytes are cancerous, they are as similar to liver cells as possible, which means they are great for modeling liver diseases in the laboratory and testing, for example, medicinal drugs. Academic adviser of the laboratory, Doctor of Biological Sciences, professor of epigenetics of N.I. Vavilov Institute of General Genetics Sergei L. Kiselev provided them to Yakut scientists.
As the head of the laboratory, Ivan Troev, noted, the uniqueness of HepG2 hepatocytes is that they maximize the function of real liver cells, so their response to various external influences can be reliably correlated with those close to reality. HepG2 hepatocytes were obtained from a teenager with primary liver cancer in the United States several years ago. Now they are spread around the world. HepG2 hepatocytes are also studied in different regions of Russia, however, they were brought to Yakutia for the first time.
Cells are planned to be used as part of a project dedicated to the development of extracorporeal artificial liver with live hepatocyte cultures. On the model of the cell, they will give an understanding of how best to use real cultures of hepatocytes in the biological circuit of the developed system.
“The entire project is dedicated to the maximum possible support of liver function for patients with irreversible processes who are only prescribed liver transplantation as the only possible treatment,” added Ivan Troev.
The project is being developed with the support of the Innovation Promotion Fund.